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cobicistat will raise the stage or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. A reduced dose of diazepam could be requiredLonafarnib may possibly improve the AUC and peak focus of CYP2C19 substrates. If coadministration unavoidable, watch for adverse reactions and lessen the CYP2C19